Biferon: Instructions for use for children and adults, forms of production, composition, analogues

Wiferon Candle analogues for children: how can the antiviral drug be replaced for a child?

Виферон: instructions for use for children and adults, forms of production, composition, analogues

One of the most popular antivirals in pediatrics is Viferon. It comes in several forms: ointment, gel, suppositories. It is usually prescribed to children in the form of rectal suppositories, because it is a convenient and safe way to administer it.

What can be substituted for the Wieferon candles for a child, which drugs are better for children of different ages, and do these drugs have analogues, which will be cheaper, but no less effective to the table of contents?

The composition and effect of the popular product on children's bodies

The main effect is provided by interferon-α 2b. Interferons are protein compounds produced by human cells as a response to a collision with a virus.

Interferon-α is leukocytic, i.e. a product of human immune system cells. But this medicine, as in most others, contains its recombinant, that is, artificially obtained variant.

He suppresses the activity of the virus, has a stimulating immunity and antiproliferative effect. It also causes a small antimicrobial effect by stimulating phagocyte cells.

It is more effective in the early days of the disease when the production of alpha interferons in the body is reduced.

Auxiliaries enhancing the effect of the drug are alpha-tocopherol acetate (better known as vitamin E) and ascorbic acid (vitamin C).

These combinations have an additional stimulating effect on immunity and contribute to the control of pathogens, which allows the use of these candles to prevent the development of bacterial infection, a frequent companion of viral diseases. Read this article about the use of the Wieferon candles for the prevention of viral diseases in children.

An analogous in composition can be called the following drugs:

  • Interferon human leukocyte;
  • Alpha Interferon;
  • Hiapheron;
  • Lifferon;
  • Grippferon;
  • Altefir;
  • Reaferone-es-lipint;
  • Lockferon;
  • Kippheron;
  • Genferon.

Analogues by action are:

  • Citovir-3;
  • Cagocel;
  • Arbidol;
  • Izprinosin;
  • Anaferon.

But these are not all the same by nosological classification or only partially the same.

The release forms are also different: not all of them are suitable for use by patients under 3 or up to 14 years of age, so a complete replacement is not always possible. Rectal suppositories appear to be one of the most convenient variants for newborns and infants.

Powders for preparation of solution containing interferon-α are presented in the market by Interferon leukocyte human, Lockferon. They require preliminary dilution and are then injected through the nasal mucosa.

These drugs are effective in respiratory viral diseases, suitable for children, but the method involves self-preparation.

A more convenient intranasal form of interferon-α – droplets or nose spray. It is presented by Grippferon.

For patients who have reached the age of three, a variant of the suspension for inward use is developed – Reaferon-EU-Lipint.

In its finished form it is not subject to long-term storage, so it is released as a pre-consumer powder. The action aims to prevent and combat upper respiratory tract diseases caused by viruses.

Rectal or vaginal candles with the same composition – Kipferon, Genferon – can also be used for children, but their range of action does not coincide fully with Wieferon.

In the pages of our website, we will talk about the indications, composition and effectiveness of these children's medicines in the form of suppositories:

  • Alginatol – used in cases of problems with the mucous membrane of the large intestine and anus.
  • Corillip – prescribed as a metabolic and strengthening medicine.
  • Viburcol – used to control acute respiratory viral infections, acute respiratory infections and some infections.
  • Panadol – has antipyretic (antipyretic), analgesic (analgesic) and mild anti-inflammatory effect. Ibuprofen.
  • Glycerin is one of the most effective laxatives.

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Kipferon – suppositories for rectal and vaginal use (in children – only rectal), contains not only interferon-α, but also a complex of immunoglobulins. This medicine fights chlamydia, viruses, pathogenic microbes and stimulates natural protection of the body.

In pediatrics, it is used for herpetic diseases, frequent inflammatory respiratory diseases and intestinal infections.

Dose single dose is calculated for children under 12 years of age according to body weight: 50 thousand IU per 1 kg, but not more than one million per day. At the maintenance in one candle 500 thousand IU it will make no more than 2 suppositories a day.

The contraindication to reception of this medicine can serve as individual intolerance of the given connection of proteins.

Side effects are extremely rare, expressed in symptoms similar to those of viral infection – nausea, weakness.

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In addition to the main active ingredient, this drug includes taurine and benzocaine. Taurine provides a regenerative effect, and benzocaine provides painkillers. Available as rectal or vaginal candles containing 250000, 500000 or 1000000 ME.

This drug is actively used in the treatment of urogenital diseases caused by both viruses and other pathogens. Children are appointed in the form of rectal suppositories, the content of interferon in a single dose should be 125 thousand ME.

There is also another version of the release of suppositories of the same brand – Genferon Light. Anesthetizing agent is excluded from the composition, available dosage – 250 and 125 thousand IU. Duration of the course – 10 days.

To enhance the therapeutic effect is recommended to take at the same time with Genferon vitamins E and C, which improve the regeneration and strengthen the immune system of the body.

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Interferon human leukocyte

The production of this medicine requires donor material – leukocytes. It is they, faced with the virus, begin to produce this protein complex. It is available in dry form as lyophilisate, in ampoules or bottles.

After dilution it is expected to be injected through the respiratory tract, either by burial in the nasal passages or by inhalation (the second form is suitable for children over 3 years of age and adults).

One of the ampoule contains 1000 IU of the active ingredient. To dilute the substance, boiled and cooled or distilled water is used (e.g. injection water).

Only open the ampoule, add water to the line, shake it until it dissolves.

Pour it up more conveniently with a syringe. The resulting solution is buried on 3-5 drops, in the first hours (3-4 hours) after the first signs of disease – every 20 minutes, then – 4 times a day. Dosage is the same for patients of all ages.

Patients with severe allergic reaction to animal proteins should be careful when administered to patients with severe allergic reaction to animal proteins.

The medicine is demanding to the temperature regime: limitation – 2-8 ° C. The prepared solution can be stored 24 hours a day.

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Lockferon

As with the previous version, it is necessary to add 4 ml of water to the contents of the vial to fight respiratory diseases of viral etiology.

The received liquid is injected into each nasal passage, in case of prevention – twice a day, in case of treatment – after 2-3 hours.

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Nasal droplets and sprays

  • Interferon Human Leukocyte. The liquid form is intended for intranasal administration. The preparation is demanding to external conditions: the temperature should be kept within 2-8 °С, after opening the bottle it is possible to use only 3 days.
  • The medicine should be taken 2 times a day on 5 drops in each nasal passage. The duration of the course is determined by the dynamics of the patient's condition, but not less than 2-3 days. As a means of preventing disease, they take it as long as there is a risk of infection.

  • Grippferon. Presented as droplets and nose spray. Can be used from an early age. Patients of the first year of life should bury one drop 5 times a day, children under 3 years old should bury two drops 3-4 times a day, children under 14 years old should bury two drops, but 5 times a day.
  • No vasoconstrictor drops should be used with it: they dry the mucous membrane of the nose, thus preventing the action of Grippferon.

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Viferon candles value depends on the dosage:

dosage Price, rub.
150000 ME (10 pieces)265
500000 ME (10 pieces))380
1000000 ME (10 pieces)541
3000000 ME (10 pieces.)969

The cost of analogues depends on the shape and dosage:

PreparationPrice, rub
Kipferon soup. and a rect. And a wag. (10 pieces)674
Interferon leukocyte human pp/internsal. introduction and inhalation. 1000 IU, bottle, 1 pc.121
Interferon leukocyte human, amp. 1000 IU (10 pcs.)101
Grippferon drops into the nose, 10000 IU/ml, 10 ml272
Grippferon nose spray 10000 IU/ml, 10 ml349
Genferon soup. a rect./vagina. 55mg + 1 mln IU + 10 mg (10 pieces)789
Genferon Superintendent/vagin. 55 mg + 500000 IU + 10 mg (10 pieces)599
Genferon Light sup./vagina. 250 thousand IU + 5 mg (10 pieces)430
Genferon Light sup./vagina. 125 thousand IU + 5 mg (10 pieces)329

Pediatric drugs containing interferon alpha are very popular with pediatricians and parents.

Little contraindications, almost no negative effects, and the possibility to use them from the first weeks of life allows their wide application.

The most convenient forms for patients of childhood are candles, drops in the nose, powders for solution preparation. Along with Wiferon Candles, available and effective medicines are Interferon Human Leukocyte, Kipferon, Grippferon, Genferon and Genferon Light.

Source: https://malutka.pro/preparaty/drugie/analogi-svechey-viferon.html

WIFERON

Wieferon: instructions for use for children and adults, forms of production, composition, analogues
Interferon. Immunomodulating agent with antiviral action

Manufacturer's form, composition and packaging

White rectal suppositories with a yellowish hue, bullet-shaped, homogeneous consistency; the heterogeneity of colouring in the form of marbling and the presence of a funnel-shaped recess on the longitudinal section; the diameter of the suppository is not more than 10 mm.

1 soup.
interferon alpha-2b human recombinant150,000 ME

Auxiliaries: α-tocopherol acetate – 55 mg, ascorbic acid – 5.4 mg, sodium ascorbate – 10.8 mg, dynasty of dihydrate edetate – 100 µg, polysorbate 80 – 100 µg, cocoa butter base and confectionery fat – up to 1 g.

10 pcs. – Cellular contour packs (1) – cardboard packs.

Rectal suppositories white with a yellowish tint, bullet-shaped, homogeneous consistency; it is allowed the heterogeneity of color in the form of marbling and the presence on the longitudinal section of the funnel-shaped depression; the diameter of the suppository is not more than 10 mm.

1 soup.
interferon alpha-2b human recombinant500 000 ME
-“-1 000 000 000 ME
-“-3 000 000 ME

Auxiliaries: α-tocopherol acetate – 55 mg, ascorbic acid – 8.1 mg, sodium ascorbate – 16.2 mg, dynasty of dihydrate edetate – 100 µg, polysorbate 80 – 100 µg, cocoa butter base and confectionery fat – up to 1 g.

10 pcs. – Cellular contour packages (1) – cardboard packages.

Pharmacological action

Interferon alpha-2b human recombinant has antiviral, immunomodulatory, antiproliferative properties, inhibits replication of RNA and DNA-containing viruses.

Immunomodulating properties of alpha-2b interferon, such as increase of phagocytic activity of macrophages, increase of specific cytotoxicity of lymphocytes to target cells, determine its mediated antibacterial activity.

In the presence of ascorbic acid and alpha-tocopherol acetate, the specific antiviral activity of interferon alpha-2b increases, its immunomodulatory effect increases, which improves the efficiency of the body's own immune response to pathogens.

With the use of the drug, the level of secretory immunoglobulins of class A increases, the level of immunoglobulin E normalizes, the endogenous system of interferon alpha-2b is restored.

Ascorbic acid and alpha-tocopherol acetate, being highly active antioxidants, have anti-inflammatory, membrane stabilizing and regenerating properties.

It has been established that there are no side effects in the course of administration of the preparation Viferon, which appear during parenteral administration of the preparations of interferon alpha-2b, no antibodies are formed which neutralize antiviral activity of interferon alpha-2b. Application of the preparation Viferon in the complex therapy allows to reduce the therapeutic doses of antibacterial and hormonal drugs, as well as to reduce the toxic effects of this therapy.

Cocoa butter contains phospholipids, which do not allow the use of synthetic toxic emulsifiers in the production, and the presence of polyunsaturated fatty acids facilitates the introduction and dissolution of the drug.

Provisions

– Acute respiratory viral infections, including influenza, including those complicated by bacterial infection, pneumonia (bacterial, viral, chlamydia) in children and adults as part of comprehensive therapy Premature, such as meningitis (bacterial, viral), sepsis, intrauterine infection (chlamydia, herpes, cytomegalovirus, enterovirus, candidiasis, etc.)h. visceral, mycoplasmosis), as part of complex therapy;

– chronic viral hepatitis B, C, D in children and adults as part of complex therapy, includingч. in combination with the use of plasmapheresis and hemosorption in chronic viral hepatitis of marked activity, complicated by cirrhosis of the liver;

– Infectious and inflammatory diseases of the urogenital tract (chlamydia, cytomegalovirus infection, ureaplasmosis, trichomoniasis, gardennerelles, papillomavirus infection, bacterial vaginosis, recurrent vaginal candidiasis, mycoplasmosis) in adults as part of a comprehensive therapy;

– primary or recurrent herpetic infection of the skin and mucous membranes, localized form, mild to moderate flow, in t.h. urogenital form in adults.

Contraindications

– hypersensitivity to any component of the drug.

Dose

Please rectally.

1 suppository contains human recombinant interferon alpha-2b as an active ingredient in the indicated dosages (150 000 ME, 500 000 ME, 1 000 000 000 ME, 3 000 000 ME).

Acute respiratory infections, including influenza, including complicated by bacterial infection, pneumonia (bacterial, viral, chlamydia) in children and adults as part of comprehensive therapy

Recomended dose for adults, including pregnant women and children over 7 years of age – Viferon 500 000 ME 1 suppository 2 times a day after 12 hours daily for 5 days. Clinically indicated therapy can be continued.

Children under 7 years of age, including newborns and premature babies with gestational age of more than 34 weeks, prescribe Viferon 150 000 ME for 1 suppository 2 times a day after 12 hours daily for 5 days. The therapy can be continued for clinical reasons. The break between the courses is 5 days.

Unborn newborns with gestational age less than 34 weeks prescribe Biferon 150 000 ME for 1 suppository 3 times a day after 8 hours a day for 5 days. The therapy can be continued for clinical reasons. The break between courses is 5 days.

Infection-inflammatory diseases of newborns, including premature infants, such as meningitis (bacterial, viral), sepsis, intrauterine infection (chlamydia, herpes, cytomegalovirus infection, enterovirus infection, candidiasis, etc.)h. visceral, mycoplasmosis) as a part of complex therapy

Recomended dose for newborn children, including prematurely born with gestational age more than 34 weeks – Viferon 150 000 ME daily for 1 suppository 2 times/day after 12 hours. Course of treatment – 5 days.

Unborn newborns with gestational age less than 34 weeks prescribe Viferon 150 000 ME daily for 1 suppository 3 times a day after 8 hours. Treatment course – 5 days.

Recomended number of courses for various infectious and inflammatory diseases: Sepsis – 2-3 courses, meningitis – 1-2 courses, herpetic infection – 2 courses, Enterovirus infection – 1-2 courses, cytomegalovirus infection -2-3 courses, mycoplasmosis, candidiasis, etc.h. visceral – 2-3 courses. The break between courses is 5 days. Clinically, therapy can be continued.

Chronic viral hepatitis B, C, D in children and adults as part of a comprehensive therapy, including in combination with the use of plasmapheresis and hemosorption in chronic viral hepatitis of marked activity, complicated by cirrhosis of the liver

Recommended dose for adults – Viferon 3 000 000 ME for 1 suppository 2 times a day after 12 hours daily for 10 days, then three times a week after 6-12 months. Treatment duration is determined by clinical efficacy and laboratory parameters.

Phildren under 6 months of age are recommended 300,000-500,000 ME/day; 6 to 12 months of age – 500,000 ME/day.

Children aged 1 to 7 years are recommended 3,000,000 ME per 1 m2 body surface area/day.

We recommend 5,000,000 ME per 1 m2 body surface area/day.

The drug is used 2 times a day after 12 hours for the first 10 days daily, then three times a week after the day for 6-12 months. Treatment duration is determined by clinical efficacy and laboratory parameters.

Daily dose calculation for each patient is performed by multiplying the recommended dose for a given age by the body surface area calculated from a nomogram to calculate the body surface area by height and weight by Garford, Terry and Roark. Calculation of a single dose is performed by dividing the calculated daily dose by 2 intakes, the resulting value is rounded up to the suppository dose.

Pri Chronic viral hepatitis of marked activity and liver cirrhosis before plasmapheresis and/or hemosorption is administered b>Children under 7 years of ageViferon 150 000 ME, Children over 7 years of age -Viferon 500 000 ME 1 suppository 2 times a day after 12 hours a day for 14 days.

Urogenital tract infections (chlamydia, cytomegalovirus, ureaplasmosis, trichomoniasis, gardennerelles, papillomavirus, bacterial vaginal vaginosis, recurrent vaginal candidiasis, mycoplasmosis) in adults, including pregnant women as part of comprehensive therapy./i>

Recomended dose for adults – Viferon 500 000 ME 1 suppository 2 times a day after 12 hours for 5-10 days. Clinically, the therapy can be continued.

Pregnant women from the second trimester of pregnancy (starting from the 14th week of gestation) are prescribed Viferon 500 000 ME by 1 suppository 2 times per day after 12 hours per day for 10 days, then 1 suppository 2 times per day after 12 hours every fourth day for 10 days.

Next, every 4 weeks before delivery – Viferon 150 000 ME 1 suppository 2 times a day after 12 hours a day for 5 days.

If necessary, appoint before delivery (from 38 weeks of gestation) Виферон 500000 ME to 1 suppository 2 times a day after 12 hours a day for 10 days.

Primary or recurrent herpetic infection of the skin and mucous membranes, localized form, mild to moderate flow, in th. urogenital form in adults, including pregnant women

Recomended dose for adults – 1,000,000 ME of vitheron 1 suppository 2 times a day after 12 hours daily for 10 days or more in case of recurrent infection. It is recommended to start treatment immediately after the first signs of skin and mucous membrane lesions (itching, burning, redness).

When treating recurrent herpes it is advisable to start treatment in the prodromal period or at the beginning of a relapse.

Pregnant women from the second trimester of pregnancy (starting with 14 weeks of gestation) are assigned to Biferon 500 000 ME, 1 suppository 2 times a day after 12 hours daily for 10 days, then 1 suppository 2 times a day after 12 hours every fourth day for 10 days.

Next, every 4 weeks before delivery – Viferon 150 000 ME 1 suppository 2 times a day after 12 hours a day for 5 days.

If necessary, shown before delivery (from 38 weeks of gestation) Biferon 500 000 ME to 1 suppository 2 times a day after 12 hours a day for 10 days.

Allergic reactions: rarely – skin rash, itching. These phenomena are reversible and disappear 72 hours after discontinuation of the drug.

Predose

Viferon overdose data not provided.

Pharmacological interaction

Wiferon is compatible and well combined with all medicines used to treat the above diseases (including antibiotics, chemotherapy, GCS).

Special instructions

Influence on driving ability and driving mechanisms

Not installed.

Pregnancy and lactation

The drug is allowed from 14 weeks of pregnancy.

Not restricted to use during lactation.

Children's use

May be indicated in children.

Vacation conditions from pharmacies

The drug is allowed as a prescription drug.

Conditions and terms of storage

The product should be kept out of reach of children and protected from light at temperatures between 2° and 8°С. Shelf life – 2 years.

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Source: https://health.mail.ru/drug/viferon_1/

Ointment, candles for children Wieferon: instructions, prices and reviews

Wieferon: instructions for use for children and adults, forms of production, composition, analogues

In this medical article, you can read about the medicine Viferon. The instructions for use will explain when you can take candles or ointments, what the medicine does for you, what are the indications, contraindications and side effects. The abstract presents the forms of drug release and its composition.

In the article, doctors and consumers can leave only real reviews about Viferon, from which you can find out whether the drug has helped in the treatment of hepatitis, herpes, influenza and other infectious diseases in adults and children, for which it is prescribed more. The instructions list the analogues of Viferon, the prices of the drug in pharmacies, as well as its use during pregnancy.

Viferon is an antimicrobial and antiviral drug. Instructions for use recommend taking 15000000 IU, 500000 IU, 1000000 IU, gel, ointment for complex therapy of various inflammatory and infectious diseases in adults and children

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