Lavomax: instructions for use in children and adults, composition, analogues of antiviral drug
Lavomax is a domestic inductor of interferon
Lavomax is another primordial Russian drug, which is used for treatment and prevention of influenza and ARVI.
Unlike its “shop colleagues” – Arbidol, Kagotsel, Ingavirin and other domestic antiviral drugs, Lavomax has been able to successfully prove its effectiveness in foreign studies.
But not as a means against respiratory viruses, but as an inductor of interferon, i.e. an immunomodulating drug.
There is no less in the Russian Federation and CIS countries Lavomax and its analogues are successfully used for the treatment and prevention of influenza and ARVI. The drug is included in the standard protocols for the treatment of respiratory viral infections as a first-line remedy along with the already mentioned domestic antiviral drugs.
The active substance Lavomax – Tiloron – was developed in the 70's of last century by an American chemist Richardson Merrell.
Literally at the same time on the other side of the globe – the Soviet Union – scientists of the Institute of Physics and Chemistry of the Academy of Sciences of the Ukrainian SSR, regardless of the American, synthesized the same tiloron.
And if Merrell, having patented the active substance, stopped there, our chemists continued research.
Tyloron was studied by scientists of Ivanovo Institute of Virology of the Academy of Medical Sciences under the guidance of F.I.Ershov.
Over the past ten years, three stages of clinical trials have been conducted, and already in 1996 the active substance was approved by the pharmacological committee of the Russian Federation.
Tyrolone has been registered as a drug for the treatment and prevention of viral infections, including influenza, hepatitis A and B, herpes simplex virus.
Since 2005 tyrolone has also been registered in Ukraine.
Lavomax composition and release forms
Lavomax tablets contain:
– Tyloron in the form of dihydrochloride in a dose of 125 mg.
Russian company Nizhpharm produces several forms of drug release, which differ only in the number of tablets in the package. Depending on the course of treatment and the purpose of Lavomax you can buy a package containing 3, 4, 6, 8, 10, 12 and even 20 tablets.
Lavomax tablets are coated with a shell, the color of which can range from yellow to orange. You can buy original tablets with a different shade than you used to. So don't rush to accuse the pharmacists of selling the counterfeit – it's just another series of Lavomax.
Lavomax's shell mainly consists of sucrose. This should be borne in mind in patients with impaired sugar cleavage.
Pure pharmacology: Peculiarities of action
Pharmacological action of Lavomax is based on stimulation of formation in the body of interferon.
Recall that interferon is a protein that is produced in the body in response to a viral attack. There are three types of interferon, each of which is needed in the immune response mechanism.
As a result of the chain of biochemical reactions triggered by interferon, the body's susceptibility to the virus is reduced.
Lavomax is able to stimulate the synthesis of all three types of interferon – alpha, beta and gamma. Interestingly, the active induction of interferon begins four hours after oral administration and lasts for a day.
Lavomax stimulates the induction of interferon in the intestinal epithelium, liver cells, as well as in blood cells – T-lymphocytes, neutrophils and granulocytes.
There is also evidence that Lavomax stimulates the formation of antibodies and corrects the ratio of T-supressors to T-helpers.
Lavomax's antiviral action is based on blocking the virus's reproduction due to inhibition of virus-specific protein in the affected cells.
It is worth noting that the interferonogenic effect of Lavomax is clinically confirmed in competent placebo-controlled studies. The immunomodulatory effect of tilorone does not raise any doubts either among domestic or foreign specialists.
Unfortunately, this cannot be said about the antiviral action. Like the vast majority of Russian antivirals, Lavomax has been and remains an unproven drug for Western developed countries. Recall that only Tamiflu and Relenza.
are recognized antivirals in Europe, the USA and other countries of the world
Pharmacokinetics: absorption and excretion of Lavomax
Tilorone is absorbed from the intestine rather quickly. However, the bioavailability of Lavomax is not very high – only about 60%. This means that 40% of the active ingredient is not absorbed into the bloodstream and, of course, has no effect.
It is important that the drug does not accumulate in the body and is excreted almost unchanged for four days after administration.
When Lavomax will help: the indications for admission
Lavomax, which has both antiviral and interferonogenic properties, is used in infections of different etiologies. We would like to note that tiloron is rarely used in monotherapy. As an immunomodulator with antiviral action, Lavomax is used as part of a comprehensive treatment in:
- virus hepatitis A, B, C;
- herpetic infection type 1 and type 2;
- cytomegalovirus infection;
- influenza and acute respiratory viral infections;
- virus encephalitis.
Interferon Lavomax is prescribed as a part of combined treatment:
- infectious allergic encephalitis;
- chlamydia infection;
- nonococcal hematopoietic surrite;
- tuberculosis of the lungs.
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In the domestic medicine, the approach that implies the mandatory inclusion of antiviral drugs in the treatment scheme of acute respiratory infections has long been rooted. Patients with influenza or respiratory viral infection are left alone with an impressive prescription after a visit to the doctor. There are more than one or two drugs on this list. Therapy has begun.
When should we wait for healing? Experience shows that flu or acute respiratory viral infections take about a week to treat. Sometimes you can achieve positive results in a shorter period of time.
“But the virus infection itself takes a week! With an adequate immune response, any respiratory virus is eliminated within seven, less often ten days.
And the elimination of the virus is a guarantee of recovery: no causative agent, so no disease.
Why then do we need antiviral drugs? Is it worth spending time and money on them?
The fact is that patients with reduced immunity may not have a harmless viral infection. The danger of influenza and acute respiratory viral infections is that the disease can be aggravated by bacterial infection.
And if respiratory viruses are doomed to death without treatment, the bacteria cannot be said to be dead. The most common complications of respiratory viral infections are bacterial sore throat, bronchitis, and, of course, pneumonia.
This already requires qualified medical attention, antibiotics, and serious treatment.
To avoid such a complicated scenario, antiviral drugs are prescribed. Children, adults with reduced immune response and the elderly in particular need them. The use of antiviral drugs, including Lavomax, has been shown to reduce the duration of the disease and the severity of symptoms.
Stimulant immunostimulants: Different views on the use
We have already said that, in contrast to the antiviral effect, the immunostimulatory effect of Lavomax is fully proven. Therefore, tiloron is mostly used as an interferon inductor. However, experts have mixed opinions about the need to use immunomodulators.
The vast majority of physicians, including immunologists, believe that an important and complex process of immune protection cannot be interfered with. Or rather, it is possible, but only after a detailed and careful study of the detailed immunogram and other indicators of the immune response.
among the adherents of this theory and most Western scientists. Therefore, tilorone drugs are not used in Europe, the U.S. and other developed countries.
Domestic physicians hold the opposite opinion, stimulating immunity without remorse, and see the positive results of treatment. The question is, who is right: immunization advocates or opponents – still open.
Lavomax – how to take it?
Lavomax therapy course depends on the disease:
– for the treatment of influenza and acute respiratory viral infections, it is recommended to take 125 mg of Lavomax in the first days of the disease, after which to reduce the frequency of administration: from the third day the drug is prescribed after a day. A course of treatment – 750 mg or six tablets;
– is enough to prevent viral infections by taking 125 mg of Lavomax only once a week. The course of treatment – six weeks;
– for the treatment of viral hepatitis take an individual course of Lavomax, which depends on both the type of hepatitis and its severity, as well as the patient's history. The duration of treatment of chronic hepatitis may be six months or even longer;
– for the treatment of infection caused by herpes simplex virus and cytomegalovirus, take 125 mg of Lavomax in the first two days of treatment, after which the drug is prescribed one tablet a day later. The course of treatment will require 20 tablets of tilorone;
– in the complex therapy of chlamydia infection prescribe 10 tablets of Lavomax according to the standard scheme: one pill for the first two days and then 125 mg every two days;
– for lung tuberculosis, Lavomax is used as an immunostimulant for the first two days, two pills each, and one pill every other day for the following days. The duration of treatment is set individually.
Lavomax in children's practice: what is the silent instructions for use?
According to the instructions for use, the prescription of Lavomax for children under 18 years of age is prohibited. However, this contraindication is not related to the toxicity or lack of clinical studies investigating the use of the drug in pediatrics.
Prescribing to use the drug in children is associated with high dosage. Thus, the full analogue of Lavomax Amixin is not only permitted for use in children over seven years of age, but is also available in a dosage of 60 mg.
The only form of release of Lavomax – tablets of 125 mg, which are forbidden to divide into parts, so it is impossible to dose the drug to a child.
Search on the effects of Lavomax during pregnancy, so the drug is prohibited to use during this period.
In addition, Lavomax is contraindicated at
- deficiency of enzymes that break down sugar (lactases and isomaltazes);
- glucose-galactose malabsorption (impaired sugar absorption);
- fructose intolerance;
- individual sensitivity to tilorone or Lavomax auxiliaries.
Typically, Lavomax is well tolerated, as evidenced by research data and patient and physician feedback. In rare cases, there may be minor adverse events that do not require withdrawal of tilorone:
– chills, which are short-term;
– allergic reactions, usually in sensitive patients;
– symptoms of dyspepsia: nausea. Vomiting and diarrhoea are rare in long-term high-dose treatment.
Lavomax's Analogues: What to Replace?
In the pharmaceutical market, there are two complete analogues of Lavomax:
1. Amixin, which is available in tablets of 125 mg and 60 mg each;
2. Thyrolone produced by Moschympharm in capsules of 125 mg each.
Thinking about pricing policy, Lavomax is somewhat cheaper than its analogues, although treatment with any tilorone cannot be called economical. However, both Lavomax and Amixin are over-the-counter drugs, which means that they are available to everyone.
The articles above and the comments written by readers are for informational purposes only and do not call for self-treatment.
Consult a specialist about your own symptoms and illnesses.
When treating any medicine, you should always use the instructions in the package with it as a basic guide, as well as your doctor's recommendations.
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Lavomax analogues: review of effective drugs
Lavomax is an effective drug that has immune-stimulating properties and has a pronounced antiviral effect. The product is used for therapeutic and preventive purposes. The drug is used for the treatment of acute viral infections, hepatitis, influenza, urethritis. However, in some situations it is necessary to choose effective lavomax analogues. So, what's the replacement medicine?
The drug characteristic
Lavomax is an antiviral drug with immunomodulatory properties that is available in tablet form. It activates the synthesis of interferons in the body. The main substance is Tyloron. The element causes the production of several types of interferon. These elements are synthesized in the liver and intestines. It also occurs in neutrophils and lymphocytes.
The use of lavomax allows for a stimulating effect on the bone marrow and leads to increased production of antibodies in the body. The product is distinguished by its activity against respiratory infection agents. It can be used to control influenza and hepatitis viruses. It also eliminates herpetic infection.
After oral use, lavomax is perfectly absorbed from the digestive system and initially leaves the body with urine and faeces. The half-life of the drug takes 2 days.
The key indications for the use of the drug are prevention and treatment of viral infections. These include the following:
The product can be used in combination therapy for chlamydia and encephalitis. It is also used to eliminate urogenital pathologies. The product can be used for treatment of children after 12 years of age. In this case, the substance helps to cope with influenza and respiratory pathologies.
Instruction for use
Drinking the medicine at high sensitivity is prohibited. Also contraindications include age less than 12 years, pregnancy and lactation. Choosing analogues cheaper than lavomax, it is necessary to familiarise with the instruction as the list of restrictions can be other.
Lavomax should be used after meal. The substance should be washed down with water. Drink 125 mg to prevent hepatitis A. It's done once a week. The therapy is carried out for 1.5 months.
To eliminate this form of hepatitis it is necessary to take the remedy according to a specific scheme. In the first day you should drink 125 mg each. It's done twice. From the second day of the day 125 mg each should be consumed at intervals of 2 days. A total of 10 tablets should be taken.
To cope with hepatitis B, on the 1st and 2nd day of therapy should be taken 125 mg. Then, with a break of 2 days, you have to use the same amount. A total of 16 drinks should be taken.
If long therapy for such hepatitis is required, 125 mg each should be taken on 1 day. It's done twice. Drink 125 mg at 2-day intervals from 2 days. A total of 20 drinks are needed
For the treatment of acute hepatitis C, it is necessary to take 125 mg of the substance once a day. It's done in the first and second day. Then it is necessary to eat 125 mg at intervals of 2 days. It is necessary to drink 20 pieces in total.
In case of development of chronic form of hepatitis C it is necessary to use in the first 2 days on 250 mg of the preparation. Then every 2 days they drink 125 mg of medicine. After taking 20 tablets, it is necessary to drink 125 mg of medicine once a week.
To cope with acute respiratory viral infections and influenza, adult patients should drink 125 mg of medicine in the first two days. You have to do it once a day. Then you have to drink 125 mg at 2-day intervals. A course of treatment costs 6 tablets.
To prepare for a seasonal epidemic, it is worth taking 125 mg of medication. It should be done once a week. In total, the prophylactic course is 1.5 months.
Lavomax is highly effective in the treatment of cytomegalovirus and herpes. You should drink 125 mg of the substance within 2 days. This is required once a day. Then they take 125 mg of medication at 2-day intervals. A total of 20 tablets should be taken.
In case of chlamydia infection, 125 mg of medication should be taken in the first 2 days. It has to be done once a day. Then you should take another 125 mg every 2 days. 10 tablets should be taken for therapy.
In the development of neuroviral pathologies, lavomax should be taken as 125-250 mg. This should be done once a day. Then you have to move on to 125 mg at intervals of 48 hours. The therapy usually lasts 2-4 weeks.
To cope with acute respiratory viral infections, adolescents over 12 years old should be given 125 mg of the product once a day. This should be done for 1, 2 and 4 days of illness. It is worth taking 375 mg of medication for the course of treatment.
In case of complications in children over 12 years old, 125 mg of the substance is shown. This should be done on the first, second, fourth and sixth day of illness. A total of 500 mg of medication is needed.
Feedback on the use of the product is mostly positive. However, sometimes the medicine causes side effects. These include allergy symptoms, minor digestive disorders, chills. In case of undesirable reactions, it is necessary to refuse to use the drug and choose an effective analogue.
Cheap Lavomax analogues review
The direct analogue of the product is a drug that has the same active ingredients. The main substance of lavomax is tilorone dihydrochloride.
The drug belongs to a group of antiviral compounds that have immunomodulatory characteristics. This is due to the ability of the substance to stimulate the synthesis of interferon.
- Tiloron can be referred to as effective analogues of lavomax.
Besides, there are lavomax generics. Such substances contain other active ingredients, but have similar properties, antiviral and immunomodulatory characteristics.
The following is referred to the recommended generics of the substance:
Lavomax or amixin – what is better
Many people are interested in: lavomax or amixin – what is better? These substances have the same composition, and therefore the principle of their action is the same. Amixin has the same admissions as the lavomax. These include the following:
They can be used as part of a combination therapy for chlamydia, pulmonary tuberculosis, and encephalitis of different genesis. The only difference is the price. Amixin costs more than lavomax.
Lavomax or Ingavirin
Lavomax or Ingavirin – which is better? The second product includes another active substance, vitagluttam. It has a more noticeable antiviral effect, but less immunomodulatory effect. However, the substance also provides the synthesis of interferon.
The key difference between lavomax and ingavirin lies in the indications for use. Ingavirin is considered to be a narrower substance. It can be used exclusively for the treatment of influenza A and B, parainfluenza. It also helps with adenovirus infection. It also helps to cope with respiratory syncytial infection.
Lavomax or Cagocel
Cagocel or Lavomax – which is better? The key component of Cagocelle is a chemical element with the same name. It has almost the same principle of action as Tyloron, which is present in lavomax.
But it only helps to cope with influenza, viral infection and herpes. It's worth considering that it's better to use Cagocel for prevention purposes.
Lavomax or cycloferon
Cycloferon is a generator based on meglumine. This substance is an interferon inductor. The drug has immunomodulatory and antiviral properties. It also helps to manage inflammation.
With this cycloferon has fewer readings to use. They include the flu, herpes and acute respiratory infections. It should be noted that this generic is twice as cheap as the original.
Attention, only TODAY!
Antiviral and immunomodulatory drug. Interferon synthesis inductor
Manufacturer's form, composition and packaging
◊ Time-coated tablets from yellow to orange, round; orange-colored tablet core.
|tilorone dihydrochloride||125 mg|
Auxiliaries: magnesium hydroxycarbonate (heavy magnesium carbonate) – 69 mg, povidone K30 – 4 mg, calcium stearate – 2 mg.
Containment composition: sugarose – 158.11 mg, povidone K17 – 5.65 mg, copovidone – 0.44 mg, magnesium hydroxycarbonate (magnesium carbonate light) – 25.7 mg, titanium dioxide – 1.
2 mg, colloidal silicon dioxide (A-380) – 1 mg, quinoline yellow dye – 0.09 mg, sunset yellow dye – 0.01 mg, macrogoal 6000-6 mg, wax bee 0.
15 mg, liquid paraffin 0.15 mg, talc 1.5 mg.
3 pcs. – Cellular contour packs (1) – cardboard packs.3 pcs. – Cellular contour packs (2) – cardboard packs.4 pcs. – Cellular contour packs (1) – cardboard packs.4 pcs. – Packages Cellular Circuit (2) – cardboard packs.
6 pcs. – Cellular contour packs (1) – cardboard packs.6 pcs. – Cellular contour packs (2) – cardboard packs.10 pcs. – Cellular contour packs (1) – cardboard packs.
10 pcs. – Cellular contour packages (2) – cardboard packages.
Ativiral and immunomodulatory agent. Lavomax stimulates the formation of α-, β-, γ-interferons in the body. In response to the injection of Lavomax, interferon is produced mainly by intestinal epithelial cells, hepatocytes, T-lymphocytes and neutrophils.
After ingestion, the maximum production of interferon is determined in the intestinal-liver-blood sequence after 4-24 h. Lavomax has immunomodulatory and antiviral effects. Stimulates bone marrow stem cells, enhances antibody formation, reduces immunosuppression, restores T-helper/T-suspension ratio depending on dose.
Effective against various viral infections, including against influenza viruses, other acute respiratory viral infections, hepatitis and herpes viruses, cytomegaloviruses and neurotrophic viruses.
Antiviral action is associated with inhibiting the transmission of viral specific proteins in infected cells, thus suppressing virus reproduction.
After ingestion of tilorone is quickly absorbed from the gastrointestinal tract. The bioavailability is 60%.
Binding to blood plasma proteins – about 80%.
Metabolism and excretion
Tiloron is not biotransformed or cumulated in the body. It is derived almost unchanged with faeces (about 70%) and urine (about 9%). T1/2 is 48 hours
The drug is used in adults as part of a comprehensive therapy:
– viral hepatitis A, B and C;
– herpetic infection;
– cytomegalovirus infection;
– infectious allergic and viral encephalitis;
– urogenital and respiratory chlamydia;
– nongonococcal urethritis;
– pulmonary tuberculosis.
Treatment and prevention of influenza and other acute respiratory infections.
– Lactation period (breastfeeding);
– Children and adolescents under 18 years of age;
– sugars/isomaltase deficiency, fructose intolerance, glucose-galactosis malabsorption (the drug contains sucrose);
– hypersensitivity to the drug components.
The drug is taken orally, after eating.
Please Treatment of influenza and other acute respiratory viral infections – in the first two days of the disease – 125 mg each, then – after a day of 125 mg each. Course dose – 750 mg (for treatment course – 6 tables of 125 mg each).
For prevention of influenza and other acute respiratory viral infections – 125 mg once a week for 6 weeks. On the course of treatment – 6 tables of 125 mg.
For treatment of viral hepatitis A – the first day of 125 mg 2 times, then – 125 mg per day. Course dose – 1.25 g (for the course of treatment – 10 tables of 125 mg each).
For treatment of acute hepatitis B – the first and second days of 125 mg each, then – 125 mg each day. Course dose – 2 g (for treatment – 16 tabs)