“Cortexin: Instructions for use in children and adults, which are prescribed, composition and analogues of Nootropics
Cortexin injections: instructions, price, analogues and reviews
From this medical article you can read about the medicine Cortexin. The instructions for use will explain when you can take the medicine, what it helps you with, what are the indications, contraindications and side effects. The abstract presents the forms of drug release and composition.
In the article, physicians and consumers can leave only real reviews about Cortexin, from which it is possible to find out whether the drug helped in the treatment of encephalopathy and cerebral blood circulation disorders in adults and children. The instructions list the analogues of Cortexin, the prices of the drug in pharmacies, and its use in pregnancy.
Nootropic, neuroprotective, antioxidant drug that improves brain activity is Cortexin.
Instructions for use recommend the use of injections for cerebral blood circulation disorders, craniocerebral injury, viral and bacterial neuroinfections, encephalopathies of various origins, asthenic syndrome, vegetative suprasegmentation disorders, memory disorders, and thinking.
Form of release and composition
Cortexin is produced in the form of lyophilisate for preparation of solution for IVM injection. The drug is sold in bottles (3 ml each), placed in contour cell packs of 5 pcs.
In one bottle of lyophilized powder for the preparation of an injection solution includes 5 or 10 mg of a complex of water-soluble polypeptide fractions (cortexin) as an active substance and 6 or 12 mg of glycine as a stabilizer.
Cortexin improves the higher functions of the brain, memory, facilitates learning, has a positive effect on the attention and resistance to stress.
The use of the drug helps protect neurons from damage by neurotoxins, increase their survival under hypoxia, oxidative stress, reduce toxicity of psychotropic substances.
Also, the drug activates reparative processes, improves the function of the cerebral cortex, the tone of the nervous system, stimulates the metabolism of neurons of the peripheral, central nervous system. The active ingredient is cortexin, the auxiliary is glycine.
What do they give Cortexin shots for?
The directions for use of the medicine include
- Brain circulation disorders;
- Supported psychomotor and speech development in children;
- Acute and chronic encephalitis and encephalomyelitis;
- Asthenic conditions;
- Craniocerebral injury and its consequences;
- encephalopathy of various genesis;
- various forms of cerebral palsy in children;
- reduced learning ability;
- nadsegmentary vegetative disorders (vegto-vascular dystonia);
- critical neonatal conditions with perinatal nervous system injuries.
Cognitive impairment (i.e.memory and thinking disorders);
Instruction for use
Cortexin is intended for use with IV.
Before injection, the contents of the vial are dissolved in 1 – 2 ml of 0.5% procaine (novocaine) solution, 0.9% sodium chloride solution or water for injection, directing the needle to the vial wall to avoid foaming. The drug is administered every day once: to children with body weight up to 20 kg in a dose of 0.5 mg/kg, with body weight over 20 kg and to adults – in a dose of 10 mg for 10 days.
If necessary, a repeated course is conducted after 3 – 6 months.
- individual intolerance to Cortexin, which can lead to side effects;
- Lactation period.
The drug is generally well tolerated. Allergic reactions may occur if the body does not take the medication.
Children, pregnant and breastfed
Cortexin is contraindicated in pregnancy due to lack of clinical trial data. If the drug needs to be prescribed during lactation, breastfeeding should be stopped (due to lack of clinical trial data).
In childhood, use is possible according to the dosing regimen.
When using 0.5% prokeine solution, information on age limits, precautions, contraindications as described in the instructions for use should be adhered to.
Dissolved powder bottle should not be stored and used after storage. It is also not recommended to mix it with other solutions.
In the case of missed injections, do not give a double dose, but give the next injection as usual on the scheduled day.
Cortexin drug analogues
Cortexin drug has no active substance analogues.
Cortexin drug does not have a similar nootropic mechanism of action:
- Glutamic acid.
- Gamma-aminobutyric acid.
- Hopanthenic acid.
Vacation conditions and price
Release from pharmacies by prescription. The average price of Cortexin (Moscow) is RUB 667. In Kiev you can buy a medicine for UAH 307, in Kazakhstan – for 4395 tenge. In Minsk, pharmacies offer a drug for 40 Belarusian rubles.
By clicking on the links, you can find out which analogues are used to treat diseases: asthenia, vegetal dystonia, cerebral palsy, cerebral palsy, cerebral circulation disorders, chmt, encephalitis, encephalitis, encephalopathy, epilepsy
Cortexin: instructions for use, analogues, price, reviews
Cortexin is a nootropic drug from the group of protein bioregulators. The action of the drug is based on its ability to normalize metabolic processes in the brain, resulting in the provision of antioxidant, anticonvulsant, nootropic, celibroprotective effects on the central nervous system.
Form of release, composition
Cortexin is presented in the form of lyophilisate for the preparation of intramuscular injection solution, there are no tablets in pharmacies.
A complex of low-molecular water-soluble peptides called cortexin.
The composition of 1 vial includes 5 (for children) or 10 (for adults) mccortexin. Glycine, an amino acid that improves brain metabolism, is used as an adjunct.
Active substances of Cortexin drugs activate neurons and neurotrophic factors of the brain, which leads to the acceleration and increase the efficiency of information transfer between different structural elements. A decrease in seizure activity and normalization of bioelectrical potential is observed due to optimization of the balance of amino acids, dopamine and serotonin.
Pharmacological activity of Cortexin is conditioned by the efficacy of the active ingredients – small by weight proteins, which after intramuscular infusion penetrate the brain and contribute to the following positive effects:
- Nootropics. The active components improve memory and learning, increase concentration, and increase resistance to psychoemotional stressors.
- Antioxidant. The drug slows down the process of lipid oxidation, prevents the negative impact of free radicals on the brain cells. Under the influence of the drug there is an increase in cell survival under conditions of oxygen starvation (hypoxia).
- Anticonvulsant. The drug helps suppress the activity of pathological foci in the brain.
- Neuroprotective action. The active ingredients reduce the toxic effects of psychotropic components and protect neurons from a number of neurotoxic factors: calcium ions, free radicals.
Cortexin also activates metabolic processes, improves the functional state of the central nervous system and increases tone. The product prevents the formation of free radicals, optimizes the balance of metabolism of excitatory and inhibitory amino acids.
Cortexin is prescribed as part of the comprehensive treatment of the following diseases and conditions:
- vegetative disorders;
- restricted speech and psychomotor development in children;
- asthenic conditions;
- encephalopathies of various origins;
- in acute or chronic encephalomyelitis and encephalitis;
- craniocerebral injuries and their possible complications;
- in various forms of cerebral palsy in children;
- in cerebral blood flow disorders;
- in reduced learning ability;
- in cognitive disorders accompanied by memory and thinking disorders.
The drug is not intended to be self-treated and should be consulted with your doctor before use.
Method of administration
Precise dosage of Cortexin and the course of treatment is determined by the doctor individually, taking into account the age of the patient and the characteristics of his body, as well as indications for the use of the drug.
Cortexin is intended for intramuscular administration.
- Before the injection of lyophilisate in the vial, it is necessary to dilute 1-2 ml of Procaine or Novocaine solution (0.5%) with water for injection or sodium chloride (0.9%).
- Powder is diluted immediately before injection because the finished product cannot be stored.
Injection should be done immediately after the finished product has been received.
Cortexin is not recommended to be mixed with other medicinal products in the same bottle. If other medications are needed, they are used separately.
If the next injection is missed, double-dose medication is not recommended. The following injection should be done in the order specified by the manufacturer in the normal mode.
How do I get injections?
The finished solution is injected into the front wall of the abdomen, the anterior side surface of the thigh (upper third), the outer upper third of the shoulder. In some cases, patients may find it easier to inject into the buttocks, but this method of administration can help to slow down the absorption of the active ingredient and cause painful seals at the injection site.
- the surface of the skin is treated with alcohol or antiseptic (Chlorhexidine, Miramistein);
- the syringe with the drug is held perpendicular to the skin, the needle is gently injected into the skin and the drug is slowly injected;
- the needle is removed, the injection site is treated with alcohol or antiseptic;
- it is recommended to retreat at least 1 cm from the previous injection at the next administration of the drug.
If intramuscular administration skills are not available, the procedure is recommended to be entrusted to a qualified health worker.
Use in childhood
Cortexin can be used in the treatment of younger age groups as prescribed and under medical supervision.
- The drug is used for motor, speech, mental, and central nervous system disorders.
- The drug is prescribed to correct the behavior of a small patient: to eliminate irritability and nervousness.
- The use of Cortexin in the treatment of schoolchildren improves memory, develops thinking, and increases concentration.
- Cortexin injections are administered to children who have suffered trauma, hypoxia, and prolonged stress.
The drug's dosage is selected according to the child's body weight. The medicine should be used once in 24 hours, the course of treatment is determined individually.
Vazhno! The powder in the bottle is not intended for division, the drug should be used once. If part of the medicine has not been used in full, the remains must be disposed of and a new bottle of the medicine must be used next time.
The medicine is well tolerated. In rare cases, hypersensitivity reactions have been reported against Cortexin.
Interaction with other drugs
Not observed any significant drug interaction of Cortexin with other groups of drugs. The drug is used as part of a comprehensive treatment regimen prescribed by a physician.
The decision on what to use is best: Cortexin or Mexidol, Piracetam, Cerebrolysine can only be taken by the attending physician, as well as the possibility and feasibility of simultaneous use of the drug with Actovegin or Pantogam. All of the above medications contribute to nootropic effects, but have different mechanisms of action.
Patients are strongly advised to refrain from self-treatment and self-selection of other medications! Clinical cases are different, treatment regimens are selected on a strictly individual basis after a comprehensive examination.
Prepared product is not intended to be stored or used after storage.
Cortexin helps to increase concentration, so it can be used by those categories of people whose professional activities require increased attention and rapid psychomotor response.
In case Procaine or Novocaine is used as a solvent, it is necessary to pay special attention to the instructions for these drugs and carefully study the manufacturer's instructions regarding contraindications, age limits, etc.e.
Storage of the preparation should be carried out in accordance with the manufacturer's recommendations: a dry place protected from sunlight with observance of the temperature regime (2-20 degrees).
Delivery of the preparation is carried out after presentation of the prescription from a doctor.
Cortexin for the period August 2017:
- Lyophilisate for the preparation of 10 mg IV solution, 10 pcs. – 1000-1200 rub.
Precise structural analogues of the medicinal product Cortexin have no analogues. If necessary, it is necessary to discuss with the doctor the possibility of using other nootropic drugs: Kavinton, Ginkgo Biloba, Winpocetin, Nootropyl, Omaron, Pantogama, Cerebrolysine.
“She went to a neurologist with complaints of excessive emotionality, examined the baby and prescribed medication, including Cortexin for children. I've heard that Cortexin's shot is called a “chatterbox.” After opening the package, she found small bottles of medicine to be diluted with anesthetic or sodium chloride.
Injections were made by a nurse in the treatment room. It's a good effect, but unfortunately, the child had an allergic reaction. The shots were given daily, only 7 out of 10 injections had to be given, after which the course of treatment had to be discontinued.
Now I see that the child's memory has improved significantly and the concentration of attention has increased: he remembers poems quickly, the studied material retells with high accuracy.”
“In junior high school, my daughter had big problems with learning and remembering the material. In preschool age, the child began to talk late, in the first grade could not yet read. All the doctors wrote that the daughter was healthy and there was no problem. As a result, we got to a smart neurologist who prescribed injections of Cortexin.
After the first injection with Novocaine, we had a strong allergy – but this is a reaction to the anesthetic element! After that, I diluted with saline solution and no more allergic reactions. We need to carefully study the instructions for the solvent. The effect is that the child is much better able to remember, the lessons are faster, the grades improve.
Cortexin injections are recommended every 3 months + Encephabol and Cogitum injections.”
“At the age of 1.5, the child only said “mother”, “daddy”, and has heard that this is not a problem, and it means that he will talk later, but the time went on and the situation did not improve by 2.5 years. Caught at a doctor's appointment, she prescribed Cortexin.
The child was very badly tolerated by injection, constantly crying, 3 days after the start of treatment said that he was afraid to go for injections. I'm a little overwhelmed, because that was almost the first thing my son said. The medicine began to work, a few days later, and there were other new words.
By the age of 3, the baby teaches and retells poems and children's stories. And I recommend all parents who have such a problem not to drag out and see doctors in time.
Have met a lot of feedback about the fact that Cortexin helps many children to “talk” and also improves memory, increases the concentration of attention.”
“The development of hydrocephalic syndrome was diagnosed in the child from birth, and there were improvements after treatment with actovegin, diacarb and asparkam. But routine ACDS, polio vaccination, and rollback and deterioration again. The doctor said that this was the effect of the vaccination and prescribed 10 injections of Cortexin.
The effect is very fast, a few days later the child began to sit down, tried to crawl, and then began to grow on the legs. Many mothers tell us that after these injections, kids start to sit and walk and babble.
The medicine is not cheap, but the effect is worth it, now we go to massages, we plan to repeat the treatment if necessary.”
“Cortexin injections are given to a child every six months after minimal brain dysfunction and delayed speech development have been identified.
Regular exercise, exercise, physiotherapy, and medication immediately entered the life of the baby, he is used to the fact that the mother regularly injects and reacts calmly. By the age of 5, the child reads a little, knows the numbers, but simple examples and tasks are not yet easy.
After each course of treatment, as well as before each visit to the doctor I always talk to the child, all of which I explain to him, who like not the mother psychologically set the child not to need treatment.”
“Cortexin injections with Aktovegin were recommended by a neurologist after complaining about weakness, low blood pressure, general malaise and dizziness. I don't know which drug worked better, but it does.
Cortexin injections are quite painful, the pain is in the leg. But it's worth it: the feeling has improved considerably, the nerves are no longer shawling, memory has improved, and stress resistance has increased.
All in all, there has been a change in attitude to many life situations, which is very pleasing.
“The course of Cortexin injections was given to a one-year-old child when a delay in speech development was detected. The medicine was used for 10 days, resulting in no effect. All the shots were given in the hospital, the child cried a lot, especially the lack of results upset him.
The doctor explained that the effect may not be immediately apparent, it will take several weeks or even months. The repeated course was recommended at the age of 2 years, but after consulting with another specialist it was decided that such a drug would not be used on a child.
It turned out that the active ingredients are obtained from the cerebral cortex of cattle, the drug is painful and it is better to use it with analgesic components (novocaine, procaine) – the doctor advised with saline solution.
As a result, the child began to talk on his own when the use of all medicines was stopped.”
Antonova Elena Mikhailovna, pharmacist
Cortexin: instructions for use, analogues and reviews, prices in Russian pharmacies
Cortexin is a nootropic agent with cerebroprotective, anticonvulsant and antioxidant effects. The active substance is cortexin, the auxiliary substance is glycine.
It contains a complex of low-molecular water-soluble polypeptide fractions penetrating through the GEB directly to nerve cells. The drug has nootropic, neuroprotective, antioxidant and tissue-specific effects.
- Nootropic – improves cortical function, learning and memory processes, concentration, stability under various stressful conditions.
- Neuroprotective – protects neurons from damage by various endogenous neurotoxic factors (glutamate, calcium ions, free radicals), reduces the toxic effects of psychotropic substances.
- Antioxidant – inhibits lipid peroxidation in neurons, increases neuronal survival under oxidative stress and hypoxia.
- Tissue-specific – activates the metabolism of neurons of the CNS and peripheral nervous system, reparative processes, improves the function of the cerebral cortex and the overall tone of the nervous system.
Cortexin application improves the higher functions of the brain, memory. It makes learning easier, increases attention, and makes patients more resistant to stressful situations.
The drug protects neurons from neurotoxins, improves their survival in oxygen deprivation and oxidative stress, and reduces the toxicity of psychotropic substances.
Activating reparative processes, improving cortical function and increasing nervous system tone. Cortexin promotes stimulation of neuronal metabolism of the central and peripheral nervous system.
1 Ampoule Contexin 5 mg for the preparation of a powder or porous injection solution for IVM injection contains:
- active ingredient: complex of water-soluble polypeptide fractions with molecular weight not exceeding 10 000 Da (cortexin) – 5 mg;
- Auxiliary substance: glycine – 6 mg.
What does Cortexin do I need? According to the instructions for use, the drug is prescribed in the following cases:
- in the treatment of craniocerebral injuries;
- in the treatment of cerebral blood flow disorders;
- in viral and bacterial neuroinfections;
- asthenic conditions;
- acute and chronic encephalitis and encephalitis;
- memory disorders;
- in memory and thinking disorders;
- in various forms of cerebral palsy in children;
- in reduced learning ability;
- in delayed psychomotor and speech development in children.
Cortexin instructions for use, dosage
The drug is intended for IV use.
Before injection, the contents of the Cortexin ampoule are dissolved in 1-2 ml 0.5% procaine (novocaine) solution, 0.9% sodium chloride solution or injection water, directing the needle to the bottle wall to avoid foaming.
The drug is administered every day once every 10 days:
- to children weighing up to 20 kg in a dose of 0.5 mg/kg;
- to adults weighing more than 20 kg;
- in a dose of 10 mg.
If necessary, a repeat course is carried out after 3-6 months. Patients with ischemic stroke are retreated 10 days after the previous stroke.
Instruction warns about the possibility of the following side effects when prescribing Cortexin:
- there may be reactions of individual sensitivity to the components of the drug.
The most frequent side effects are pain and burning at the injection site, and less often allergic rashes or urticaria occur.
Cortexin is contraindicated in the following cases:
- individual intolerance to the drug;
Ampoule with the dissolved product cannot be stored and used after storage.
Not registered overdose cases.
Cortexin Analogues, pharmacy price
If necessary, Cortexin can be replaced with an ATC analogue – these are drugs:
Similar in action:
- Ginko biloba;
When choosing analogues, it is important to understand that Cortexin instructions, prices and reviews do not apply to drugs with similar effects. It is important to consult a doctor and not to make an independent replacement of the drug.
Price in pharmacies in Russia: ampoules Cortexin 10mg., 10 units – from 786 to 1194 rubles, lyophilisate 10 mg 5 ml 10 pcs. – 1207 rubles, Cortexin for children lyophilisate 5 mg 10 pcs – RUB 754 to RUB 786