Atarax: Instructions for use for children and adults, analogues of the tranquilizer
Manufacturer's form, composition and packaging
White coated tablets white, oblong, with a transversal separating risk on both sides.
|hydroxysine hydrochloride||25 mg|
Auxiliary substances: microcrystalline cellulose (Avicel PH102), colloidal anhydride silicon (Aerosil 200), magnesium stearate, lactose monohydrate, Opadrai Y-1-7000 (titanium dioxide, hydroxypropyl methylcellulose 2910 5cP, macrogol 400).
25 pcs. – blisters (1) – cardboard packs.
Derived from biphenylmethane has moderate anxiolytic activity; it also has sedative, antiemetic, antihistamine and m-cholinoblocking action.
Blocks central m-cholinoreceptors and histamine H1-receptors and inhibits the activity of certain subcortical zones. It does not cause mental addiction and addiction.
Clinical effect occurs 15-30 minutes after ingestion.
Has a positive effect on cognitive abilities, improves memory and attention. Relaxes skeletal and smooth muscles, has bronchodilating and analgesic effects, moderate inhibitory effect on gastric secretion. Hydroxyzine significantly reduces itching in patients with urticaria, eczema and dermatitis. Polysomnography in patients with insomnia and anxiety clearly demonstrates the lengthening of sleep, reduction of the frequency of night waking after a single or repeated use of hydroxysine at a dose of 50 mg.
Decrease in muscle tension in patients with anxiety noted when taking the drug at a dose of 50 mg.3 times a day.
Hydroxysin is highly absorbed from the GIT. Cmax is observed 2 hours after taking the drug.
After a single dose of the drug in a single dose of 25 mg or 50 mg in adults, the concentration in plasma is 30 ng / ml and 70 ng / ml, respectively.
Bioavailability at ingestion and in/injection is 80%.
Hydroxysin is more concentrated in tissues (particularly in the skin) than in plasma. The distribution coefficient is 7-16 l/kg.
Hydroxysin penetrates through the GEB and placental barrier, concentrating more in the fetal tissue than in the mother's body. Metabolites are found in breast milk.
Metabolism and excretion
Hydroxysin is metabolized in the liver. The main metabolite (45%) is cetyrizine, which is a blocker of histamine H1-receptors. The total clearance of hydroxylsine is 13 ml/min/kg. T1/2 in adults is 14 hours. Only 0.8% of hydroxysine is excreted unchanged in urine.
Pharmacokinetics in special clinical cases
All children have 4 times less total clearance than adults, T1/2 in children aged 14 is 11 hours, in children aged 1 year – 4 hours.
In elderly patients, T1/2 is 29 h, the distribution coefficient is 22.5 l/kg.
In patients with liver dysfunction T1/2 is increased to 37 h, the concentration of metabolites in serum is higher than in young patients with normal liver function. Antihistamine effect may persist for 96 hours
– Adults: to relieve anxiety, psychomotor agitation, feelings of internal tension, increased irritability in neurological, mental (including Generalized anxiety, adaptation disorders) and somatic diseases, chronic alcoholism; withdrawal syndrome in chronic alcoholism accompanied by psychomotor agitation;
– as a sedative during the period of premedication;
– skin itching (as a symptomatic therapy).
— the period of labour;
– the period of lactation (breastfeeding);
– Hypersensitivity to drug components;
– hypersensitivity to cetyrizine and other piperazine derivatives, aminophylline or ethylenediamine.
Not recommended to prescribe Atarax tablets for patients with hereditary intolerance to galactose, as well as with impaired absorption of glucose and galactose, as the tablets include lactose.
C Cautionshould be administered the drug for myasthenia, prostate hyperplasia with clinical manifestations, difficulty in urination, constipation, increased intraocular pressure, dementia, a tendency to seizures; in case of predisposition to arrhythmia development; concomitant use of drugs with arrhythmogenic effect; concomitantly with other CNS suppressants or cholinoblockers (dose reduction required). Reduced dose of the drug is required in patients with severe and moderate renal failure, hepatic failure, and elderly patients with reduced glomerular filtration.
The drug is taken orally
For symptomatic itching treatment children aged 12 months to 6 years The drug is administered in a daily dose of 1-2.5 mg/kg body weight in several doses; to children over 6 years of age – in a dose of 1-2 mg/kg/day in several dosages.
For premedication to children the drug is administered in a dose of 1 mg/kg of body weight 1 hour before the operation, as well as in the night before the operation.
Adultsfor symptomatic treatment of anxiety is administered in a dose of 25-100 mg/day in several sessions during the day or overnight. The average dose is 50 mg/day (12.5 mg in the morning, 12.5 mg in the afternoon and 25 mg at night). If necessary, the dose can be increased up to 300 mg/day.
For symptomatic treatment of itching the initial dose is 25 mg, if necessary, the dose can be increased by 4 times (25 mg 4 times/day).
Maximum single dose should not exceed 200 mg, maximum daily dose should not exceed 300 mg
U Older patients initial dose should be reduced by half.
Patients with moderate to severe renal failureand liver failureneed dose reduction.
Side effects associated with anticholinergic action: rare (mainly in elderly patients) – dry mouth, delayed urination, constipation, impaired accommodation.
Central Nervous System: drowsiness, general weakness (especially at the beginning of treatment), headache, dizziness. If weakness and drowsiness do not disappear after a few days of therapy, the dose should be reduced. Very rarely (at a significant overdose) – tremors, seizures, disorientation.
Cardiovascular system: Arterial hypotension, tachycardia.
Side of the digestive system: nausea, changes in liver function tests.
Pregnancies: increased sweating, allergic reactions, fever, bronchospasm.
No clinically significant respiratory depression was observed at the recommended doses. Involuntary motor activity (including very rare cases of tremors and seizures), disorientation has been observed with a significant overdose.
Side effects observed when taking Atarax are usually mild, transient and disappear after a few days of treatment or after dose reduction.
Symptoms: increased anticholinergic effects, depression or paradoxical CNS stimulation, nausea, vomiting, involuntary motor activity, hallucinations, unconsciousness, arrhythmia, arterial hypotension; rarely tremors, seizures, disorientation that occur with a significant overdose.
Treatment: if there is no spontaneous vomiting, it must be induced or the stomach rinsed. Carry out general activities aimed at maintaining the vital functions of the body and monitor the patient until the symptoms of intoxication disappear in the next 24 hours
If it is necessary to obtain a vasopressor effect, norepinephrine or metaramenol is prescribed. Epinephrine should not be used. There is no specific antidote. Hemodialysis is ineffective.
Atarax potentiates the effects of drugs suppressing the CNS, such as opioid analgesics, barbiturates, tranquilizers, sleeping pills, ethanol (combinations require individual dosage selection).
Atarax, when used simultaneously, prevents the pressurization of epinephrine (adrenaline) and anticonvulsant activity of phenytoin, as well as the action of beta-histine and cholinesterase blockers.
Atarax does not affect the activity of atropine, belladonna alkaloids, cardiac glycosides, hypotensive agents, blockers of histamine H2-receptors.
Atarax should be avoided in combination with MAO inhibitors and cholinoblockers.
Hydroxysin is an isoenzyme inhibitor of CYP2D6 and may cause interaction with CYP2D6 substrates when used in high doses. Since hydroxyzine is metabolized in the liver, an increase in its concentration in the blood can be expected when combined with liver enzyme inhibitors.
Atarax should be stopped 5 days prior to the study if allergic tests are required.
Patients taking Atarax should refrain from drinking alcohol.
Influence on the ability to drive and drive mechanisms
Patients taking Atharax should be warned, if necessary, that the drug may affect concentration and speed of psychomotor reactions.
Pregnancy and lactation
Atarax is contraindicated in pregnancy, during childbirth.
Application in childhood
For symptomatic treatment of itching to children aged 12 months to 6 years the drug is administered in a daily dose of 1-2.5 mg/kg body weight in several doses; to children over 6 years of age – in a dose of 1-2 mg/kg/day in several dosages.
For premedication to childrenthe drug is administered in a dose of 1 mg/kg of body weight 1 hour before the operation, as well as on the night before the operation.
In renal dysfunction
Patients with Medium and severe renal failureneed a dose reduction.
In liver dysfunction
Patients with liver failureneed dose reduction.
Administration in old age
Dose reduction is required in elderly patients with a decrease in glomerular filtration.
Vacation conditions from pharmacies
Conditions and terms of storage
The product should be kept out of reach of children and in a dry place at temperatures not exceeding 25°C. Shelf life – 5 years.
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Atarax: instructions for use, analogues and reviews, prices in Russian pharmacies
Atarax is a tranquilizer with an anxiolytic, anti-emetic and sedative action. Blocks central choline receptors and histamine H1 receptors and inhibits the activity of certain subcortical zones.
Not causing mental dependence and addiction. Clinical effect occurs 15-30 minutes after taking the drug orally.
Has a positive effect on cognitive abilities, improves memory and attention. Relaxes skeletal and smooth muscles, has bronchodilating and analgesic effects, moderate inhibitory effect on gastric secretion. Atarax significantly reduces itching in patients with urticaria, eczema and dermatitis.
No withdrawal or impairment of cognitive function was observed on prolonged administration.
The main active ingredient of the product is dihydrochloride hydroxylsine. Although the drug is not a CNS depressant, it can have a depressing effect on the activity of some subcortical areas.
Polysomnography in patients with insomnia and anxiety clearly demonstrates the lengthening of sleep, reduction in the frequency of night waking after a single or repeated use of pills. Decrease in muscle tension in patients with anxiety was observed when taking Atarax in a dose of 50 mg 3 times/day.
Hydroxysin is quickly absorbed from the gastrointestinal tract. Cmax is marked after 2 hours after taking the product. After a single dose of the product in a single dose of 25 mg or 50 mg in adults, the concentration in plasma is 30 ng/ml and 70 ng/ml, respectively. The bioavailability for ingestion and ingestion is 80%.
The total clearance for babies is 4 times lower than for adults, T1/2 for babies aged 14 years is 11 hours, for babies aged 1 year – 4 hours. In elderly patients, T1/2 is 29 hours, with a distribution coefficient of 22.5 l/kg.
What does Atarax do to help? Prescribe a drug to relieve irritation, tension, as a calming CNS, so use it in the following cases:
- The main symptomatic indicator of its use is skin itching. The drug does not eliminate the cause of the disease (eczema, urticaria, dermatitis), but only blocks its manifestations.
- The withdrawal syndrome with psychomotor arousal (the so-called “withdrawal” in the rejection of alcohol, drugs, nicotine, etc.).
- Travoga, tension, psychomotor agitation and irritability, in neurological, somatic and mental disorders.
- Tension and anxiety in the pre-operative period.
- Postpartum depression.
Atarax is an anti-anxiety drug that inhibits the activity of some subcortical areas. It has antispasmodic and antihistamine action, increases the total duration of sleep.
Atarax Instructions and Dosage
The drug is taken orally or injected in/m.
For symptomatic treatment of itching in children:
- at the age of 1 to 6 years the drug is administered in a daily dose of 1-2.5 mg/kg body weight in several doses;
- at the age of over 6 years – in a dose of 1-2 mg/kg/day in several dosages.
For children, the drug is administered in a dose of 1 mg/kg body weight 1 hour before the operation, as well as in the evening before the operation.
Adults are administered in a dose of 25-100 mg/day for symptomatic treatment of anxiety in a few doses during the day or overnight. The average dose is 50 mg/day (12.5 mg in the morning, 12.5 mg/day and 25 mg/night).
- The dose can be increased up to 300 mg/day if necessary
For surgical premedication, a dose of 50-200 mg/day is administered to the patient (1.5-2.For symptomatic itching treatment the initial dose is 25 mg, if necessary it can be increased 4 times (25 mg 4 times a day). The maximum single dose should not exceed 200 mg; the maximum daily dose should not exceed 300 mg.
Olderly patients are treated at half the dose. In case of renal and/or hepatic insufficiency, the dose should be reduced.
Memoires that the dosage depends on the body's response to the therapy and is selected individually by the doctor. The duration of treatment is also determined only by the attending physician, the normal duration is four weeks, but depending on the patient's condition and diagnosis, the physician may change these values.
Atarax administration is contraindicated in the following cases:
- High sensitivity to any of the drug's components, cetyrizine and other piperazine derivatives, aminophylline or ethylenediamine;
- period of delivery;
- period of breastfeeding.
- inherited galactose intolerance, glucose-galactose absorption disorder (as the tablets contain lactose).
- myasthenia; clinical hyperplasia of the prostate, including difficulty in urinating, constipation;
- increasing intraocular pressure;
- A tendency to seizures;
- the sick, prone to arrhythmia, or receiving medications that may cause arrhythmia;
- Patients treated simultaneously with other CNS suppressants or choline-blockers (dose should be reduced);
- patients with severe and severe renal failure and liver failure (dose reduction is necessary);
- old patients (dose reduction in case of reduced glomerular filtration.
Probable side effects on Atarax prescription:
- dry mouth,
- acute increase in intraocular pressure,
- acute urine retention,
- disruption of accommodation,
- reduction of hell,
- increased sweating,
- increased activity of “liver” transaminases,
- allergic reactions.
Interaction with alcohol and other drugs
- In concomitant administration of Atarax with drugs that have an overwhelming effect on the CNS, its effect on the body increases, which should be taken into account when determining the dosage.
- No concomitant administration of Atarax with drugs of the group of MAO inhibitors and cholinoblockers is allowed.
- Pro simultaneous administration of the drug with Cimetidine increases hydroxysine in plasma.
- No simultaneous administration of medications suppressing CNS function is recommended due to the increased effect of their administration.
- Atarax is known to stop the anticonvulsant effects of phenytoin and adrenaline.
- It has been noted that the drug's effect is enhanced when taking alcoholic beverages.
Analogues and prices of Atarax, list of drugs
If necessary, it is possible to replace Atarax with a structural analogue – it is a drug called Hydroxysin.
The following synonyms and substitutes for Atarax are distinguished:
When choosing analogues, it is important to understand that the instructions for use of Atharax, the price, and feedback do not apply to drugs with similar effects. It is important to consult a doctor and not to make an independent replacement of the drug.
In pharmacies in Russia, it is sold strictly by prescription. The price depends on the pharmacy and the form of production, on average, is 272-369 rubles per pack of tablets of 25 mg
What's better – Phoenibut or Atarax?
Phoenibut is an antihypoxic and nootropic drug. This drug effectively relieves anxiety, tension, normalizes sleep. The cost of a pack of Phoenibut (20 pcs.) is about 160 rubles
But this drug is not a complete analogue, because the active ingredient of Phoenibut – amino-phenyl butyric acid. Therefore, only a physician can decide to replace one drug with another.
Atarax: instructions for use, patient reviews, price, radar, side effects
Atarax is a Belgian-made tranquilizer successfully used in psychiatry.
One of the few anciolitic drugs allowed for younger patients (from 12 months).
Has many contraindications, is dangerous for the development of severe adverse reactions. For this reason, it is dispensed from pharmacies strictly according to a prescription in Latin.
After the Medicines Registry has an INN Hydroxysin.
Hydroxybased drug. It has a sedative, antihistamine effect. It has a positive effect on cognitive function and helps to increase concentration.
Capable of alleviating zood in skin diseases.
In the event of severe anxiety and chronic insomnia, hydroxysin reduces the regularity of night waking up, increases the duration of a good, calm sleep, and the positive result is noticeable after the first use of the pill.
The composition includes additional components – titanium dioxide, cellulose, lactose, magnesium stearate, macrogel, hydroxypropyl methylcellulose.
Atarax is assigned for what?
- alarming states;
- sense of internal tension;
- < excessive irritability;
- abstinence syndrome.
Propossible prescription for the treatment of itching (used as a symptomatic treatment for eczema, psoriasis, dermatitis).
This symptom is common in patients with mental disorders.
Instructions for use and dosage
How to take the medicine determines the doctor depending on the patient's diagnosis.
General recommendations are presented below:
- Treatment of anxiety, withdrawal syndrome. Depending on the diagnosis of the patient and the severity of his illness, prescribed up to 100 mg, the drug should be taken during the day or once before bedtime (at the discretion of the attending physician). If necessary, the dosage can be increased up to 300 mg.
- Treatment of itching. Appointed on a tablet up to 4 times a day. Maximum daily dose – 300 mg.
Children after reaching 1 year dose of Atharax is administered according to age and weight, calculated from 1 to 2.5 mg per body weight.
The number of pills assigned is divided into several tricks per day.
Disclaimed in case of individual intolerance to the elements included in the composition.
Categorically prohibited for prescription in pregnant women.
If it is necessary to take the drug during lactation, breastfeeding should be suspended during therapy.
In case of non-compliance with the doctor's prescription dose of Atarax, the likelihood of overdose is high and is manifested:
- central nervous system oppression;
- involuntary motor activity;
- < nausea;
- disturbance of consciousness;
- by hallucinations;
- by arterial hypotension;
- by arrhythmia;
- by tremors, convulsions;
- by disorientation in space.
Average cost in Russia – 330 rubles per 25 tablets.
Tranquilizer belongs to the drugs of group B – potent drugs sold from pharmacies strictly by prescription.
In order to buy Atarax, you must have a prescription in Latin.
Atarax and Alcohol
Inappropriate to take alcohol during therapy, compatibility is negative.
Atarax has a powerful effect on a person's psychoemotional state, and alcohol has the same effect. The drug and alcohol duo can cause not only serious mental health problems, but also the patient to become mortally dangerous.
At the same time, a minimum dose of alcohol will lead to adverse reactions that will appear in an increased form.
High risk of severe intoxication of the body. Cases of fatal outcome in combination of Atarax and alcoholic beverages are known.
Feedback from patients who have taken the drug
Few real-life feedbacks from patients treated with Atarax:
Vladimir, 29 years old, Yeisk:
The psychiatrist has prescribed Atarax pills. I noticed the improvements quickly enough, after a couple of days of therapy I felt calm, increased mood. The only drawback to the pills was that I really wanted to sleep during the day. But this phenomenon was noticed only in the first days of treatment.
Katerina, 34 years old, Kaliningrad:
Softening came after the first pill taken