Amoxicillin: directions for use, release forms for children and adults, antibiotic analogues
Instruction on the use of amoxicillin in tablets for adults and children + reviews
Amoxicillin refers to semi-synthetic penicillins with bactericidal mechanism of activity. According to statistics, this is the most “bought” tablet antibiotic. Only azithromycin products can compete with it in terms of sales. What is the reason why the product is so popular with doctors and consumers?
Amoxicillin – instructions for use of the 500 mg tablet by adults
How to take amoxicillin according to the official instructions? Although the bioavailability of the drug does not depend on eating, in order to reduce the likelihood of dyspeptic disorders of the gastrointestinal tract, it is recommended to use Table
before eating or at the beginning of the meal. Pills may not be chewed, shredded or broken (except for Flemoxin Solyutab). The antibiotic is drunk with a glass of non-carbonated, boiled water. Do not use juices, milk, tea or carbonated beverages.
Table Flamoxin can be chewed, dissolved in water to the consistency of the syrup (20-30 milliliters of water) or suspensions (from 100 milliliters). As in the previous case, only non-carbonated, boiled water is used.
The course of administration is from seven to 14 days.
Treatment duration is determined:
- the severity of the disease;
- the rate of positive dynamics;
- the sensitivity of the pathogen;
- localization of the infectious and inflammatory process;
- presence of background (aggravating) pathologies.
Amoxicillin is an antibiotic or not?
Amoxicillin is an antibacterial agent. Pharmacological group – penicillins with an extended spectrum of antimicrobial activity.
One is an improved modification of ampicillin. Unlike its predecessor, amoxicillin is acid-resistant and highly digestible during oral administration. Its bioavailability is independent of food intake.
The drug is able to be fully absorbed in the intestines and create high, stable concentrations in the blood in a short period of time. However, its concentration in the lower parts of the gastrointestinal tract is quite low, so it is not prescribed for the treatment of intestinal infections.
As well as ampicillin, it is completely destroyed by bacterial enzymes (beta-lactamases), so it is not prescribed for the treatment of infections caused by beta-lactamase-producing strains.
Amoxicillin is a release form and composition
Amoxicillin is recommended as a suspension or syrup for children. It is not recommended that babies under five years of age should be given the table and caps.
- Soluble soluble form of Flemoxin Solyutab, produced by the Dutch pharmaceutical company Astellas, has the form of a table with the content of antibiotics of 125, 250, 500 and 1000 milligrams. The price of 230, 280, 360, 480 rubles. for packing of 20 tablets accordingly.
Photo Flemoksin Solyutab 1000 mg
Advanced contains microcrystalline and dispersable cellulose, flavors and sweeteners.
- Amoxicillin of the Serbian campaign Chemofarm in pellet format for the production of oral suspension, the dosage of 250 milligrams in five milliliters (bottle of 100 ml) will cost the Russian buyer in 120 rubles.
Photo Amoxicillin in suspensions
Photo Amoxicillin in suspensions
An addition to the composition of the drug includes thickeners, sweeteners, flavorings.
- Amoxicillin capsules of 250 mg and 500 mg each contain 250 and 500 milligrams of amoxicillin trihydrate, respectively. Produced by the Serbian campaign Chemofarm (about 70 rubles per package of 16 tablets),
- amoxicillin tablets of 250 and 500 mg each contain, respectively, 250 and 500 milligrams of amoxicillin trihydrate.
Photo Amoxicillin in tablets
An additional components are potato starch, lactulose, crosscarmellose sodium, crosspovidone, talcum, polysorbate-80 and magnesium stearate.
Produced by the Russian companies Biochemist Saransk and AVVA RUS (packaging of five hundred milligrams – 70 rubles),
Pillages for 250 milligrams of production Synthesis ASOMP (trade name Amosin) will cost the buyer in 40 rubles.
- Powder for the manufacture of an oral suspension (Amosin 250 mg in 3 grams. The package contains 10 bags) and costs about 50 rubles. One package contains 250 milligrams of amoxicillin trihydrate.
Read more: Excellent selection of amoxicillin analogues for adults and children
Amoxicillin recipe in Latin (solutab form – Flemoxini Solutabi)
Rp: Tab. Amoxicillini 1.0D.t.d: No. 20 in tab.
S: 1 table each. 3 ppm
Why does amoxicillin help?
Antibacterial action of bactericidal nature is caused by the ability of antibiotics to disrupt the synthesis of supporting polymers of cell membranes of pathogens at the time of their division, leading to lysis of bacteria.
The drug is effective for staphylococcal (excluding beta-lactamase-producing types) and streptococcal infections. Also works on gong- and meningococcus, echerichia coli, shigella, klebsiella, salmonella, hemophilus stick, helikobacter pylori (appointed in combination with metronidazole), etc. Moderately active against chlamydia.
Not used against strains producing beta-lactamase enzyme, rickettsia, mycoplasmus, morganella, serrations, sweat, enterobacter and viruses. Also not active against ampicillinresistant bacteria.
What is the use of amoxicillin with clavulanic acid for?
This is due to the ability of some microorganisms to produce enzymes that inactivate the effect of the antibiotic, the drug is enhanced with a beta-lactamase inhibitor.
Clavulanic acid is capable of forming stable compounds with bacterial enzymes, preventing inactivation and destruction of the antibiotic.
The use of amoxicillin in combination with clavulanic acid contributes to the expansion of the antimicrobial spectrum due to the effectiveness of the combined drugs against beta-lactamazproducing strains of bacteria.
Amoxicillin – Indications for use
The drug well overcomes the histochemical barrier and creates therapeutic concentrations in organs and tissues. Like other antibiotics from the penicillin group, it does not overcome the unchanged hemato-encephalic barrier.
Antibiotic is effective if the inflammatory process is involved:
- Upper and lower respiratory tract;
- urogenital system;
- skin and PPE;
Also available for the treatment of uncomplicated forms of gonorrhea, leptospirosis, salmonellosis, meningitis, Lyme disease, endocarditis, and pylori as part of the treatment of helikobacter.
Amoxicillin's field of application is due to the fact that it accumulates:
- peritoneal fluid;
- skin, blisters and subcutaneous fat;
- pulmonary tissue
- gastrointestinal mucosa
- mid ear fluid;
- gallbladder and bile fabrics;
- fabrics of the fetus (this is due to the fact that, cf. can overcome the placental barrier).
li>fabrics and female genital mucous membranes;
In the case of a severe course of infection, it is preferable to use amoxicillin with clavulanic acid, in tablet or injection form (amoxicillin in ampoules). Stage therapy can be used (transition from parenteral to oral use).
Amoxicillin – contraindications
Antibiotic is not prescribed in cases: individual intolerance to penicillins, infectious mononucleosis, lymphatic leukemia.
Sp>Sp-in should be used with caution if a patient has allergic conditions of various genesis, bronchial asthma, gastrointestinal pathologies, kidney and liver failure, pregnancy and lactation. Amoxicillin in breastfeeding is prescribed only under the control of the attending physician.
Also, it is not recommended to prescribe it in patients with antibiotic-associated diarrhea or colitis in the history.
When used concurrently with metronidazole, for the eradication of helikobacter pylori, CNS and blood diseases are added to the main contraindications.
Read more: How to take probiotics when taking antibiotics and which are better
The expected benefit to the mother should be higher than the anticipated risk to the future child.
Permissibility of prescribing is due to the lack of data on mutagenic, teratogenic and embryotoxic effects on the foetus.
However, no controlled and large-scale studies have been conducted, and therefore amoxicillin is prescribed in pregnancy, but is classified as an FDA – B.
, that is, the absence of a negative effect on the fetus was confirmed by an animal study.
Amoxicillin during breastfeeding
Antibiotic in small amounts penetrates and is released with breast milk. Therefore, amoxicillin in breastfeeding can be administered strictly on the basis of indications and under the supervision of the attending physician. Given the risk of sensitisation, dysbiosis, diarrhoea and thrush infection in the child during lactation, it may be advisable to temporarily discontinue breastfeeding.
Amoxicillin dosage to adults
Start daily dose for patients over ten years of age with a body weight of more than forty kilograms is 1500 mg (3 tablets of 500), divided into three dosages.
Patients with uncomplicated gonorrhea (acute current) are recommended to take three grams of antibiotics once every eight hours for the treatment of severe infections. Women need to take the drug for two days.
Automatic gastrointestinal diseases of infectious and inflammatory nature and gynecological infections – from one and a half to 2 grams three times a day or from 1 to 1.5 grams every six hours.
Leptospirosis – 500 to 750 mg every six hours.
Salmonellosity – 1.5 to 2 grams, duration of treatment – from two weeks to a month.
Prophylaxis of endocarditis in surgery – from 3 to 4 grams one hour before surgery. It is possible to take the drug again after eight hours.
In case of a reduced SCF, the dose or time interval between doses is corrected, depending on the rate of glomerular filtration.
Dose of amoxicillin in suspensions for children
The dose to children under two years old is calculated by 20 milligrams per kilogram of weight, the drug is administered three times a day. In severe infections, the dosage can be increased to 60 milligrams per kg.
Neon-birth and prematurity are indications for reducing the dose or increasing the interval between doses.
From two to five years of age take 125 milligrams every eight hours.
From five to 10 – 0.25 grams, every eight hours.
For children aged 10 years, with a weight of more than 40 kilograms are prescribed adult dosage.
How is the suspension diluted?
Diluted at room temperature, the suspension can be stored for up to two weeks. Only clean, non-carbonated water can be used as a solvent.
Water is added to the powder bottle for the manufacture of the suspension and thoroughly mixed. Shake the mixture before each use.
Five milliliters of suspension contain 250 ml of antibiotics.
Amoxicillin side effects and effects
Amoxicillin allergies are most common. Other undesirable effects may include dysbacteriosis and thrush. Sometimes patients complain about changes in taste, nausea and abdominal pain. In rare cases, antibiotic-associated diarrhoea and colitis may develop.
Patients with immunodeficiency may develop superinfection.
The CNS may have anxiety, insomnia, dizziness, seizures.
As well as changes in tests (increased liver transaminases, decreased white blood cells, platelets, and neutrophils, rare anemia).
Amoxicillin and Alcohol – Compatibility
While penicillins are not on the list of drugs with disulphyrim-like effects, alcoholic beverages combined with antibiotics can cause liver and CNS damage, drug overdose, and severe intoxication. So amoxicillin and alcohol are incompatible. It is recommended to stop drinking alcohol for the duration of treatment.
Amoxicillin can be released under trade names:
Amoxicillin – Physician Reviews
The drug has been widely used in medical practice for many years and has repeatedly proven its effectiveness. Its advantages include good digestibility and patient acceptance.
A wide range of dosages and many forms of release (suspensions, capsules, pellets, tablets, soluble form) allow the patient to choose the most convenient form for him.
It is also worth noting the low cost of the drug, which distinguishes it from other antibiotics.
From the side effects the most common are allergies to amoxicillin, thrush and dysbacteriosis. The rest are quite rare. Gastrointestinal disorders can be avoided by taking the product according to the instructions, i.e. before eating.
infectionist Chernenko A. L.
Read more: Eliminating fever after antibiotics in a child and adult
Amoxicillin: instructions for use for adults and children, antibiotic release forms, composition, analogues
- 1 Forms of production, composition
- 2 Pharmacological properties and indications for use
- 3 Age restrictions on admission
- 4 Amoxicillin instructions for children and adults
- 5 Amoxicillin for pregnancy and lactation
- 6 Can alcohol be consumed while taking the drug?
- 7 Drug interactions with other drugs
- 8 Contraindications, side effects and overdose
- 9 Analogues of Amoxicillin antibiotics
Amoxicillin antibiotic belongs to the penicillin group and is highly active with respect to various pathogens. Semisynthetic component by principle of action and properties, it has much in common with ampicillin, but is more effective, better absorbed by the body.
The drug is available in the following forms:
- standard capsules;
- dry powder used to prepare injections;
- internal solution;
Amoxicillin tablets are considered the most popular.
The medications are coated with a coating, so the entire dose of the active ingredient goes directly to the organs of the gastrointestinal tract, from where it is distributed with blood throughout the body. Tablets containing 500 mg or 1 g.
Prescription medicine is available for sale.
Active component of the medicine is amoxicillin trihydrate. The set of auxiliary components depends on the form of production. For example, the tablets contain cellulose, magnesium stearate, talc, titanium dioxide, etc.
Pharmacological properties and indications for use
Amoxicillin antibiotic acts in several directions, has a wide range of applications, has an antimicrobial, bactericidal effect. The substance is resistant to acidic environments. The component penetrates into the cell structure of the pathogenic bacteria, stops the growth and development of microbes, makes them unable to reproduce.
The drug is highly active against microorganisms that cause salmonellosis, gonorrhea, meningitis, streptococcus, staphylococcus.
Amoxicillin is useless against bacteria that can produce penicillinase.
Effect of using antibiotics occurs within 30 minutes after administration, maintained up to 8 hours.
The drug is shown for such diseases and disorders:
- bronchitis, otitis, maxillary sinusitis;
- gonorrhea, cystitis;
- abdominal typhoid, dysentery;
- dermatoses of bacterial origin;
- sepsis, meningitis, etc.;
“Amoxicillin” is useful for ENT, gastrointestinal, skin, and urogenital infections. The drug is ineffective in the fight against viral etiology.
The advantage of this medicine is that it has a mild but quick and effective effect on the body. This tool can significantly improve the patient's condition on the first day of treatment.
“Amoxicillin” will help reduce the recovery period. There are no age restrictions on the use of the drug – it is prescribed to both adults and children. Dose is determined on the basis of the patient's age and weight, the degree of the disease, and the patient's state of health.
Amoxicillin Guidelines for Children and Adults
Nelsius to start without first consulting a specialist, especially if the antibiotic is used to treat a child. It is essential that the doctor's instructions are followed and that the doctor's recommendations are adhered to. It's the only way to achieve a rapid, expressive therapeutic effect.
Methods of administration and dosing mode
Amoxicillin tablets 500 mg are absorbed by water, regardless of the dosing mode. Babies who cannot swallow this form of medicine are crushed into powder and diluted with liquid.
Standard daily dosages for infectious diseases:
- 750 mg – 3 g – adults;
- 25 – 50 mg per 1 kg of weight – “Amoxicillin” for children under 10 years of age or weighing up to 40 kg;
- 500 mg – adults with severe kidney disease
- 15 mg/kg – children diagnosed with kidney failure.
If the drug is used to prevent the development of endocarditis, it is administered in a dose of 3 g once every 1 hour before surgery and then another 3 g after 6 hours if necessary. Amoxicillin therapy can be short and normal.
In the first case, the duration of the course – 2 applications of 3 g with an interval of 10 – 12 hours. In the second – 2 – 3 days.
For infections caused by streptococcal activity, therapy should continue for 10 days until complete eradication of the pathogen is achieved.
Specific instructions for taking antibiotics
Before prescribing “Amoxicillin”, make sure that the patient is not hypersensitive to cephalosporins and penicillins. Anaphylactic reactions may occur during the use of the drug, which may endanger the life and health of the patient.
If the patient is accompanied by severe diarrhea, prescribe an antibiotic in a peripheral form. During prolonged therapy, it is necessary to constantly monitor, because the risk of superinfection increases due to reduced sensitivity to amoxicillin in pathogens.
Amoxicillin in pregnancy and lactation
Pregnant women are prescribed amoxicillin-based medications if the expected benefit to the patient exceeds the possible harm to the fetus.
If the use of an antimicrobial medicine is not possible during the breastfeeding period, a temporary switch to artificial.
should be considered
May I consume alcohol while taking the drug?
To avoid alcoholic beverages during Amoxicillin therapy. Alcohol increases the likelihood of side effects, creates additional stress on the liver and kidneys.
Pharmacological interaction with other drugs
Amoxicillin is usually well combined with drugs from other pharmacokinetic categories. Still, some combinations can have a negative impact on the patient's health.
Not recommended to combine the use of “Amoxicillin” with the use of such drugs:
- other antimicrobial drugs;
Amoxicillin-based drugs have the ability to reduce the efficacy of hormonal contraceptives, affecting the concentration of progesterone and estrogen in the blood.
This nuance must be taken into account and barrier methods used.
Contraindications, side effects and overdose
Absolute contraindication to the use of Amoxicillin is hypersensitivity to penicillin group substances. The instructions for use state that the drug is contraindicated for children under 3 years of age, however, paediatricians prescribe the drug to babies from birth, if necessary.
- Kidney failure, severe;
- disturbance of gastrointestinal tract organs;
- mononucleosis of infectious origin;
- bronchial asthma;
- colitis in anamnesis caused by antibiotics.
Patients who have been diagnosed with diabetes need to take the product with caution because the tablets contain sucrose.
Amoxicillin may cause side effects. If the drug is used for a long time, there is a risk of superinfection when the microorganisms develop resistance to the active substance.
Single cases of anemia, leukopenia and other disorders of the hematopoietic system have been recorded, which, however, take place after the termination of therapy.
The most common side effects are abdominal discomfort, meteorism, swelling, diarrhea, etc.
Excess antibiotic dose is not accompanied by dangerous effects.
With a high overdose, there may be a disturbance of the water-electrolytic balance, abnormal functioning of the digestive system.
Patients with kidney pathologies are at high risk of developing crystalluria. The drug doesn't have the antidote. Overdose therapy is aimed at eliminating symptoms and alleviating the patient's condition.
Analyogues of the Amoxicillin antibiotic
A range of drugs, in which the main active ingredient is amoxicillin, is quite extensive. On the shelves of pharmacies you can find medicines in the form of tablets (250 mg, 500 mg, 1 g), capsules, injectable solutions. Analogues of “Amoxicillin” differ from this drug by composition, price.
The list of the most popular substitutes can include medicines with such trade names:
- “Amoxicillin Ecobol”;
- “Flemoxin Solyutab”;
- “Augmentin”, etc.
Positive feedback from patients about Flamoxin Solyutab.
This is a next-generation antibiotic that effectively destroys amoxicillin-sensitive pathogens.
The antimicrobial agent has a limited list of contraindications, in rare cases it is accompanied by unpleasant symptoms.
Do not prescribe any medication without consulting your doctor, especially if it is a child's treatment.
The choice of medication and the determination of the dose should be based on clinical tests, symptoms of the disease.
The use of inappropriate medication or an abnormal regimen can cause unpleasant and, in some cases, life-threatening consequences (e.g. anaphylactic shock).
Amoxicillin: cheap analogues to replace the drug for adults and children
Systemic antibiotics often supplement comprehensive ENT therapy. They can be used only for prescription and only when the pathology is of bacterial origin.
Amoxicillin, which belongs to the group of penicillins, is often used in practice, is produced in different forms, has many analogues of domestic and foreign production.
Antibiotic has a wide range of effects, but also a large list of side effects and contraindications. That's why many people are looking for cheap analogues of Amoxicillin with the same action, but at an affordable price